American Airlines flight AA 4381: Multiple routes

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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Daily 08:20 Ronald Reagan Washington (DCA) 2 10:08 Boston Logan (BOS) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:48 Effective 2026-07-02 through 2026-08-04
Mon-Fri,Sun 09:56 Chicago O'Hare (ORD) 3 11:45 Omaha (OMA)
AA 4381 Non-stop Embraer EMB 175 (E75) 1:49 Effective 2026-03-08 through 2026-04-06
Daily 10:08 New York LaGuardia (LGA) B 12:01 John Glenn Columbus (CMH)
AA 4381 Non-stop Embraer EMB 175 (E75) 1:53 Effective 2026-08-05 through 2026-09-08
Sat 10:10 John Glenn Columbus (CMH) 11:57 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:47 Effective 2026-01-10 through 2026-02-07
Daily 10:38 John Glenn Columbus (CMH) 12:32 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:54 Effective 2026-02-12 through 2026-03-07
Mon-Fri,Sun 10:45 John Glenn Columbus (CMH) 12:32 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:47 Effective 2026-01-06 through 2026-02-11
Daily 10:52 Boston Logan (BOS) B 12:45 Ronald Reagan Washington (DCA) 2
AA 4381 Non-stop Embraer EMB 175 (E75) 1:53 Effective 2026-07-02 through 2026-08-04
Mon,Tue,Fri,Sun 10:54 John Glenn Columbus (CMH) 12:45 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:51 Valid until 2026-01-05
Thu 11:40 John Glenn Columbus (CMH) 13:31 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:51 Operates only on 2026-01-01
Daily 12:14 John Glenn Columbus (CMH) 13:59 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:45 Effective 2026-08-05 through 2026-09-08
Daily 12:59 New York LaGuardia (LGA) B 14:23 Charlottesville (CHO)
AA 4381 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:24 Effective 2026-05-21 through 2026-07-01
Daily 14:43 New York LaGuardia (LGA) B 16:43 Detroit (DTW) E
AA 4381 Non-stop Embraer EMB 175 (E75) 2:00 Effective 2026-09-09 through 2026-10-04
Daily 15:01 Charlottesville (CHO) 16:29 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:28 Effective 2026-05-21 through 2026-07-01
Daily 15:14 New York John F. Kennedy (JFK) 8 17:09 Cleveland (CLE)
AA 4381 Non-stop Embraer EMB 175 (E75) 1:55 Effective from 2026-10-05
Daily 15:35 Philadelphia (PHL) 17:00 Boston Logan (BOS) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:25 Effective 2026-04-07 through 2026-05-20
Daily 17:25 Detroit (DTW) E 19:12 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:47 Effective 2026-09-09 through 2026-10-04
Daily 17:40 Cleveland (CLE) 19:29 New York John F. Kennedy (JFK) 8
AA 4381 Non-stop Embraer EMB 175 (E75) 1:49 Effective from 2026-10-05
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4381: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4381
08:20
Ronald Reagan Washington (DCA) 2

10:08
Boston Logan (BOS) B
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:48, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4381
09:56
Chicago O'Hare (ORD) 3

11:45
Omaha (OMA)
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:49, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4381
10:08
New York LaGuardia (LGA) B

12:01
John Glenn Columbus (CMH)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:53, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4381
10:10
John Glenn Columbus (CMH)

11:57
New York LaGuardia (LGA) B
Effective 2026-01-10 through 2026-02-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:47, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4381
10:38
John Glenn Columbus (CMH)

12:32
New York LaGuardia (LGA) B
Effective 2026-02-12 through 2026-03-07
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:54, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4381
10:45
John Glenn Columbus (CMH)

12:32
New York LaGuardia (LGA) B
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:47, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4381
10:52
Boston Logan (BOS) B

12:45
Ronald Reagan Washington (DCA) 2
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:53, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4381
10:54
John Glenn Columbus (CMH)

12:45
New York LaGuardia (LGA) B
Valid until 2026-01-05
Mon
Tue
Wed
-
Thu
-
Fri
Sat
-
Sun
Duration: 1:51, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4381
11:40
John Glenn Columbus (CMH)

13:31
New York LaGuardia (LGA) B
Operates only on 2026-01-01
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Duration: 1:51, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4381
12:14
John Glenn Columbus (CMH)

13:59
New York LaGuardia (LGA) B
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:45, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4381
12:59
New York LaGuardia (LGA) B

14:23
Charlottesville (CHO)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:24, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4381
14:43
New York LaGuardia (LGA) B

16:43
Detroit (DTW) E
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:00, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4381
15:01
Charlottesville (CHO)

16:29
New York LaGuardia (LGA) B
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:28, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4381
15:14
New York John F. Kennedy (JFK) 8

17:09
Cleveland (CLE)
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:55, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4381
15:35
Philadelphia (PHL)

17:00
Boston Logan (BOS) B
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:25, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4381
17:25
Detroit (DTW) E

19:12
New York LaGuardia (LGA) B
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:47, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4381
17:40
Cleveland (CLE)

19:29
New York John F. Kennedy (JFK) 8
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:49, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Boston Logan (BOS) - Ronald Reagan Washington (DCA)
  • Chicago O'Hare (ORD) - Omaha (OMA)
  • Cleveland (CLE) - New York John F. Kennedy (JFK)
  • Detroit (DTW) - New York LaGuardia (LGA)
  • New York LaGuardia (LGA) - Charlottesville (CHO)
  • New York LaGuardia (LGA) - John Glenn Columbus (CMH)
  • Philadelphia (PHL) - Boston Logan (BOS)
All American Airlines flights
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