American Airlines flight AA 4421: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 05:10 Oklahoma City (OKC) 07:22 Chicago O'Hare (ORD) 3
AA 4421 Non-stop Embraer EMB 175 (E75) 2:12 Valid until 2025-05-04
Daily 05:16 Oklahoma City (OKC) 07:30 Chicago O'Hare (ORD) 3
AA 4421 Non-stop Embraer EMB 175 (E75) 2:14 Effective 2025-12-03 through 2025-12-17
Daily 05:17 Oklahoma City (OKC) 07:30 Chicago O'Hare (ORD) 3
AA 4421 Non-stop Embraer EMB 175 (E75) 2:13 Effective 2025-12-18 through 2026-02-11
Daily 05:22 Oklahoma City (OKC) 07:30 Chicago O'Hare (ORD) 3
AA 4421 Non-stop Embraer EMB 175 (E75) 2:08 Effective from 2026-02-12
Daily 08:15 Ronald Reagan Washington (DCA) 2 09:50 Wilmington (ILM)
AA 4421 Non-stop Embraer EMB 175 (E75) 1:35 Effective 2025-10-26 through 2025-11-01
Daily 08:19 Ronald Reagan Washington (DCA) 2 09:54 Pensacola (PNS)
AA 4421 Non-stop Embraer EMB 175 (E75) 2:35 Effective 2025-07-05 through 2025-08-05
Daily 10:24 Pensacola (PNS) 13:49 Ronald Reagan Washington (DCA) 2
AA 4421 Non-stop Embraer EMB 175 (E75) 2:25 Effective 2025-07-05 through 2025-08-05
Mon-Sat 11:10 New York LaGuardia (LGA) B 12:51 Greensboro/High Point (GSO)
AA 4421 Non-stop Embraer EMB 175 (E75) 1:41 Effective 2025-06-06 through 2025-06-18
Sat 11:15 Philadelphia (PHL) 12:34 Norfolk (ORF)
AA 4421 Non-stop Embraer EMB 175 (E75) 1:19 Effective 2025-05-10 through 2025-05-17
Mon-Sat 11:15 Philadelphia (PHL) 12:34 Norfolk (ORF)
AA 4421 Non-stop Embraer EMB 175 (E75) 1:19 Effective 2025-05-19 through 2025-05-31
Mon-Wed,Sun 11:15 Philadelphia (PHL) 12:34 Norfolk (ORF)
AA 4421 Non-stop Embraer EMB 175 (E75) 1:19 Effective 2025-06-01 through 2025-06-04
Thu 11:22 New York LaGuardia (LGA) B 13:03 Greensboro/High Point (GSO)
AA 4421 Non-stop Embraer EMB 175 (E75) 1:41 Operates only on 2025-06-05
Sun 11:39 New York LaGuardia (LGA) B 13:22 Greensboro/High Point (GSO)
AA 4421 Non-stop Embraer EMB 175 (E75) 1:43 Effective 2025-06-08 through 2025-06-15
Daily 11:43 Hartford (BDL) 13:27 Chicago O'Hare (ORD) 3
AA 4421 Non-stop Embraer EMB 175 (E75) 2:44 Effective 2025-09-03 through 2025-10-05
Sat 13:24 Greensboro/High Point (GSO) 14:59 New York LaGuardia (LGA) B
AA 4421 Non-stop Embraer EMB 175 (E75) 1:35 Effective 2025-06-07 through 2025-06-14
Mon-Thu 13:25 Greensboro/High Point (GSO) 15:00 New York LaGuardia (LGA) B
AA 4421 Non-stop Embraer EMB 175 (E75) 1:35 Effective 2025-06-09 through 2025-06-18
Fri 13:27 Greensboro/High Point (GSO) 15:02 New York LaGuardia (LGA) B
AA 4421 Non-stop Embraer EMB 175 (E75) 1:35 Effective 2025-06-06 through 2025-06-13
Thu 13:33 Greensboro/High Point (GSO) 15:08 New York LaGuardia (LGA) B
AA 4421 Non-stop Embraer EMB 175 (E75) 1:35 Operates only on 2025-06-05
Sun 13:54 Greensboro/High Point (GSO) 15:29 New York LaGuardia (LGA) B
AA 4421 Non-stop Embraer EMB 175 (E75) 1:35 Effective 2025-06-08 through 2025-06-15
Daily 19:45 Ronald Reagan Washington (DCA) 2 21:53 Tallahassee (TLH)
AA 4421 Non-stop Embraer EMB 175 (E75) 2:08 Effective 2025-08-06 through 2025-09-02
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4421: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4421
05:10
Oklahoma City (OKC)

07:22
Chicago O'Hare (ORD) 3
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:12, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
05:16
Oklahoma City (OKC)

07:30
Chicago O'Hare (ORD) 3
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:14, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
05:17
Oklahoma City (OKC)

07:30
Chicago O'Hare (ORD) 3
Effective 2025-12-18 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:13, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
05:22
Oklahoma City (OKC)

07:30
Chicago O'Hare (ORD) 3
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:08, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
08:15
Ronald Reagan Washington (DCA) 2

09:50
Wilmington (ILM)
Effective 2025-10-26 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:35, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
08:19
Ronald Reagan Washington (DCA) 2

09:54
Pensacola (PNS)
Effective 2025-07-05 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:35, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
10:24
Pensacola (PNS)

13:49
Ronald Reagan Washington (DCA) 2
Effective 2025-07-05 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:25, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
11:10
New York LaGuardia (LGA) B

12:51
Greensboro/High Point (GSO)
Effective 2025-06-06 through 2025-06-18
Mon
Tue
Wed
Thu
Fri
Sat
Sun
-
Duration: 1:41, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
11:15
Philadelphia (PHL)

12:34
Norfolk (ORF)
Effective 2025-05-10 through 2025-05-17
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:19, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
11:15
Philadelphia (PHL)

12:34
Norfolk (ORF)
Effective 2025-05-19 through 2025-05-31
Mon
Tue
Wed
Thu
Fri
Sat
Sun
-
Duration: 1:19, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
11:15
Philadelphia (PHL)

12:34
Norfolk (ORF)
Effective 2025-06-01 through 2025-06-04
Mon
Tue
Wed
Thu
-
Fri
-
Sat
-
Sun
Duration: 1:19, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
11:22
New York LaGuardia (LGA) B

13:03
Greensboro/High Point (GSO)
Operates only on 2025-06-05
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Duration: 1:41, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
11:39
New York LaGuardia (LGA) B

13:22
Greensboro/High Point (GSO)
Effective 2025-06-08 through 2025-06-15
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 1:43, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
11:43
Hartford (BDL)

13:27
Chicago O'Hare (ORD) 3
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:44, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
13:24
Greensboro/High Point (GSO)

14:59
New York LaGuardia (LGA) B
Effective 2025-06-07 through 2025-06-14
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:35, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
13:25
Greensboro/High Point (GSO)

15:00
New York LaGuardia (LGA) B
Effective 2025-06-09 through 2025-06-18
Mon
Tue
Wed
Thu
Fri
-
Sat
-
Sun
-
Duration: 1:35, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
13:27
Greensboro/High Point (GSO)

15:02
New York LaGuardia (LGA) B
Effective 2025-06-06 through 2025-06-13
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Duration: 1:35, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
13:33
Greensboro/High Point (GSO)

15:08
New York LaGuardia (LGA) B
Operates only on 2025-06-05
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Duration: 1:35, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
13:54
Greensboro/High Point (GSO)

15:29
New York LaGuardia (LGA) B
Effective 2025-06-08 through 2025-06-15
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 1:35, non-stop
Embraer EMB 175 (E75)
American Airlines AA4421
19:45
Ronald Reagan Washington (DCA) 2

21:53
Tallahassee (TLH)
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:08, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Hartford (BDL) - Chicago O'Hare (ORD)
  • New York LaGuardia (LGA) - Greensboro/High Point (GSO)
  • Oklahoma City (OKC) - Chicago O'Hare (ORD)
  • Philadelphia (PHL) - Norfolk (ORF)
  • Ronald Reagan Washington (DCA) - Pensacola (PNS)
  • Ronald Reagan Washington (DCA) - Tallahassee (TLH)
  • Ronald Reagan Washington (DCA) - Wilmington (ILM)
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