American Airlines flight AA 4521: Multiple routes

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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Daily 05:35 Nashville (BNA) 07:30 Chicago O'Hare (ORD) 3
AA 4521 Non-stop Embraer EMB 175 (E75) 1:55 Effective 2025-12-18 through 2026-01-05
Daily 05:36 Nashville (BNA) 07:30 Chicago O'Hare (ORD) 3
AA 4521 Non-stop Embraer EMB 175 (E75) 1:54 Effective 2025-11-02 through 2025-12-02
Daily 09:00 Pittsburgh (PIT) 09:52 Chicago O'Hare (ORD) 3
AA 4521 Non-stop Embraer EMB 175 (E75) 1:52 Effective 2025-09-03 through 2025-10-05
Daily 09:00 Ronald Reagan Washington (DCA) 2 11:29 Jacksonville (JAX)
AA 4521 Non-stop Embraer EMB 175 (E75) 2:29 Effective 2025-10-06 through 2025-10-25
Daily 10:19 Chicago O'Hare (ORD) 3 12:44 John Glenn Columbus (CMH)
AA 4521 Non-stop Embraer EMB 175 (E75) 1:25 Effective 2025-05-05 through 2025-06-04
Daily 10:20 Chicago O'Hare (ORD) 3 12:48 John Glenn Columbus (CMH)
AA 4521 Non-stop Embraer EMB 175 (E75) 1:28 Valid until 2025-05-04
Daily 12:20 Chicago O'Hare (ORD) 3 15:32 Hartford (BDL)
AA 4521 Non-stop Embraer EMB 175 (E75) 2:12 Effective 2026-01-06 through 2026-02-11
Daily 12:29 Jacksonville (JAX) 14:24 Ronald Reagan Washington (DCA) 2
AA 4521 Non-stop Embraer EMB 175 (E75) 1:55 Effective 2025-10-06 through 2025-11-01
Daily 13:10 Chicago O'Hare (ORD) 3 16:31 Hartford (BDL)
AA 4521 Non-stop Embraer EMB 175 (E75) 2:21 Effective 2025-12-03 through 2025-12-17
Daily 13:10 Chicago O'Hare (ORD) 3 16:23 Hartford (BDL)
AA 4521 Non-stop Embraer EMB 175 (E75) 2:13 Effective from 2026-02-12
Daily 13:24 John Glenn Columbus (CMH) 13:58 Chicago O'Hare (ORD) 3
AA 4521 Non-stop Embraer EMB 175 (E75) 1:34 Effective 2025-05-05 through 2025-06-04
Sat 13:28 John Glenn Columbus (CMH) 14:02 Chicago O'Hare (ORD) 3
AA 4521 Non-stop Embraer EMB 175 (E75) 1:34 Valid until 2025-05-03
Mon,Wed-Fri,Sun 13:34 John Glenn Columbus (CMH) 14:08 Chicago O'Hare (ORD) 3
AA 4521 Non-stop Embraer EMB 175 (E75) 1:34 Valid until 2025-05-04
Daily 17:56 Hartford (BDL) 19:50 Chicago O'Hare (ORD) 3
AA 4521 Non-stop Embraer EMB 175 (E75) 2:54 Effective from 2026-02-12
Daily 18:01 Hartford (BDL) 19:50 Chicago O'Hare (ORD) 3
AA 4521 Non-stop Embraer EMB 175 (E75) 2:49 Effective 2026-01-06 through 2026-02-11
Daily 18:07 Hartford (BDL) 19:50 Chicago O'Hare (ORD) 3
AA 4521 Non-stop Embraer EMB 175 (E75) 2:43 Effective 2025-12-03 through 2025-12-17
Fri 20:09 New York LaGuardia (LGA) B 21:50 Buffalo (BUF)
AA 4521 Non-stop Embraer EMB 175 (E75) 1:41 Effective 2025-06-06 through 2025-06-27
Mon-Thu,Sun 20:29 New York LaGuardia (LGA) B 22:03 Buffalo (BUF)
AA 4521 Non-stop Embraer EMB 175 (E75) 1:34 Effective 2025-06-05 through 2025-07-03
Mon-Fri,Sun 20:29 New York LaGuardia (LGA) B 22:08 Buffalo (BUF)
AA 4521 Non-stop Embraer EMB 175 (E75) 1:39 Effective 2025-07-06 through 2025-08-05
Daily 21:15 New York LaGuardia (LGA) B 22:44 Buffalo (BUF)
AA 4521 Non-stop Embraer EMB 175 (E75) 1:29 Effective 2025-08-06 through 2025-09-02
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4521: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4521
05:35
Nashville (BNA)

07:30
Chicago O'Hare (ORD) 3
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:55, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
05:36
Nashville (BNA)

07:30
Chicago O'Hare (ORD) 3
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:54, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
09:00
Pittsburgh (PIT)

09:52
Chicago O'Hare (ORD) 3
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:52, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
09:00
Ronald Reagan Washington (DCA) 2

11:29
Jacksonville (JAX)
Effective 2025-10-06 through 2025-10-25
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:29, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
10:19
Chicago O'Hare (ORD) 3

12:44
John Glenn Columbus (CMH)
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:25, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
10:20
Chicago O'Hare (ORD) 3

12:48
John Glenn Columbus (CMH)
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:28, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
12:20
Chicago O'Hare (ORD) 3

15:32
Hartford (BDL)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:12, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
12:29
Jacksonville (JAX)

14:24
Ronald Reagan Washington (DCA) 2
Effective 2025-10-06 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:55, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
13:10
Chicago O'Hare (ORD) 3

16:31
Hartford (BDL)
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:21, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
13:10
Chicago O'Hare (ORD) 3

16:23
Hartford (BDL)
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:13, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
13:24
John Glenn Columbus (CMH)

13:58
Chicago O'Hare (ORD) 3
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:34, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
13:28
John Glenn Columbus (CMH)

14:02
Chicago O'Hare (ORD) 3
Valid until 2025-05-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:34, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
13:34
John Glenn Columbus (CMH)

14:08
Chicago O'Hare (ORD) 3
Valid until 2025-05-04
Mon
Tue
-
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:34, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
17:56
Hartford (BDL)

19:50
Chicago O'Hare (ORD) 3
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:54, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
18:01
Hartford (BDL)

19:50
Chicago O'Hare (ORD) 3
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:49, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
18:07
Hartford (BDL)

19:50
Chicago O'Hare (ORD) 3
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:43, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
20:09
New York LaGuardia (LGA) B

21:50
Buffalo (BUF)
Effective 2025-06-06 through 2025-06-27
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Duration: 1:41, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
20:29
New York LaGuardia (LGA) B

22:03
Buffalo (BUF)
Effective 2025-06-05 through 2025-07-03
Mon
Tue
Wed
Thu
Fri
-
Sat
-
Sun
Duration: 1:34, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
20:29
New York LaGuardia (LGA) B

22:08
Buffalo (BUF)
Effective 2025-07-06 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:39, non-stop
Embraer EMB 175 (E75)
American Airlines AA4521
21:15
New York LaGuardia (LGA) B

22:44
Buffalo (BUF)
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:29, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Hartford (BDL) - Chicago O'Hare (ORD)
  • John Glenn Columbus (CMH) - Chicago O'Hare (ORD)
  • Nashville (BNA) - Chicago O'Hare (ORD)
  • New York LaGuardia (LGA) - Buffalo (BUF)
  • Pittsburgh (PIT) - Chicago O'Hare (ORD)
  • Ronald Reagan Washington (DCA) - Jacksonville (JAX)
All American Airlines flights
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