American Airlines flight AA 5621: Multiple routes

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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Daily 07:54 Greenville/Spartanburg (GSP) 09:45 Philadelphia (PHL) F
AA 5621 Non-stop Canadair CRJ 900 (CR9) 1:51 Effective 2025-10-06 through 2025-11-01
Daily 07:56 Greenville/Spartanburg (GSP) 09:50 Philadelphia (PHL) F
AA 5621 Non-stop Canadair CRJ 900 (CR9) 1:54 Effective 2025-12-03 through 2025-12-17
Daily 07:57 Greenville/Spartanburg (GSP) 09:50 Philadelphia (PHL) F
AA 5621 Non-stop Canadair CRJ 900 (CR9) 1:53 Effective 2025-08-06 through 2025-09-02
Daily 07:59 Greenville/Spartanburg (GSP) 09:50 Philadelphia (PHL) F
AA 5621 Non-stop Canadair CRJ 900 (CR9) 1:51 Effective 2025-12-18 through 2026-01-05
Daily 08:01 Greenville/Spartanburg (GSP) 09:50 Philadelphia (PHL) F
AA 5621 Non-stop Canadair CRJ 900 (CR9) 1:49 Effective 2026-01-06 through 2026-02-11
Daily 08:02 Greenville/Spartanburg (GSP) 09:50 Philadelphia (PHL) F
AA 5621 Non-stop Canadair CRJ 900 (CR9) 1:48 Effective from 2026-02-12
Daily 08:03 Greenville/Spartanburg (GSP) 09:50 Philadelphia (PHL) F
AA 5621 Non-stop Canadair CRJ 900 (CR9) 1:47 Effective 2025-11-02 through 2025-12-02
Daily 16:25 Charlotte (CLT) 17:44 Milwaukee (MKE)
AA 5621 Non-stop Canadair CRJ 900 (CR9) 2:19 Valid until 2025-05-04
Daily 16:55 Charlotte (CLT) 18:08 Milwaukee (MKE)
AA 5621 Non-stop Canadair CRJ 900 (CR9) 2:13 Effective 2025-05-05 through 2025-06-04
Daily 18:14 Milwaukee (MKE) 21:24 Charlotte (CLT)
AA 5621 Non-stop Canadair CRJ 900 (CR9) 2:10 Valid until 2025-05-04
Daily 18:38 Milwaukee (MKE) 21:50 Charlotte (CLT)
AA 5621 Non-stop Canadair CRJ 900 (CR9) 2:12 Effective 2025-05-05 through 2025-06-04
Tue,Wed,Sat 22:37 Charlotte (CLT) 23:59 Savannah (SAV)
AA 5621 Non-stop Canadair CRJ 900 (CR9) 1:22 Effective 2025-07-05 through 2025-08-05
Tue,Wed,Sat 22:39 Charlotte (CLT) 23:53 Savannah (SAV)
AA 5621 Non-stop Canadair CRJ 900 (CR9) 1:14 Effective 2025-06-07 through 2025-07-02
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This flight number is listed as serving the following routes:


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American Airlines flight AA 5621: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA5621
07:54
Greenville/Spartanburg (GSP)

09:45
Philadelphia (PHL) F
Effective 2025-10-06 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:51, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5621
07:56
Greenville/Spartanburg (GSP)

09:50
Philadelphia (PHL) F
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:54, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5621
07:57
Greenville/Spartanburg (GSP)

09:50
Philadelphia (PHL) F
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:53, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5621
07:59
Greenville/Spartanburg (GSP)

09:50
Philadelphia (PHL) F
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:51, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5621
08:01
Greenville/Spartanburg (GSP)

09:50
Philadelphia (PHL) F
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:49, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5621
08:02
Greenville/Spartanburg (GSP)

09:50
Philadelphia (PHL) F
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:48, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5621
08:03
Greenville/Spartanburg (GSP)

09:50
Philadelphia (PHL) F
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:47, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5621
16:25
Charlotte (CLT)

17:44
Milwaukee (MKE)
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:19, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5621
16:55
Charlotte (CLT)

18:08
Milwaukee (MKE)
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:13, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5621
18:14
Milwaukee (MKE)

21:24
Charlotte (CLT)
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:10, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5621
18:38
Milwaukee (MKE)

21:50
Charlotte (CLT)
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:12, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5621
22:37
Charlotte (CLT)

23:59
Savannah (SAV)
Effective 2025-07-05 through 2025-08-05
Mon
-
Tue
Wed
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:22, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5621
22:39
Charlotte (CLT)

23:53
Savannah (SAV)
Effective 2025-06-07 through 2025-07-02
Mon
-
Tue
Wed
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:14, non-stop
Canadair CRJ 900 (CR9)
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This flight number is listed as serving the following routes:
  • Charlotte (CLT) - Milwaukee (MKE)
  • Charlotte (CLT) - Savannah (SAV)
  • Greenville/Spartanburg (GSP) - Philadelphia (PHL)
All American Airlines flights
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