Delta Air Lines flight DL 421: Multiple routes

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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Daily 12:15 Detroit (DTW) M 13:29 Las Vegas Harry Reid (LAS) 1
DL 421 Non-stop Boeing 757 (757) 4:14 Effective 2025-06-08 through 2025-07-06
Daily 12:15 Detroit (DTW) M 13:50 Las Vegas Harry Reid (LAS) 1
DL 421 Non-stop Airbus A321 (321) 4:35 Effective 2025-12-20 through 2026-01-05
Daily 12:27 Detroit (DTW) M 13:50 Las Vegas Harry Reid (LAS) 1
DL 421 Non-stop Boeing 757 (757) 4:23 Effective 2025-05-07 through 2025-06-07
Daily 12:55 Detroit (DTW) M 14:13 Las Vegas Harry Reid (LAS) 1
DL 421 Non-stop Boeing 737-900 (739) 4:18 Effective 2025-07-07 through 2025-08-10
Daily 12:55 Detroit (DTW) M 14:13 Las Vegas Harry Reid (LAS) 1
DL 421 Non-stop Boeing 757 (757) 4:18 Effective 2025-08-11 through 2025-09-07
Daily 12:55 Detroit (DTW) M 14:39 Las Vegas Harry Reid (LAS) 1
DL 421 Non-stop Airbus A321 (321) 4:44 Effective from 2026-01-06
Daily 12:58 Detroit (DTW) M 14:23 Las Vegas Harry Reid (LAS) 1
DL 421 Non-stop Airbus A321 (321) 4:25 Valid until 2025-05-06
Daily 14:50 Las Vegas Harry Reid (LAS) 1 21:58 Detroit (DTW) M
DL 421 Non-stop Boeing 737-900 (739) 4:08 Effective 2025-07-07 through 2025-08-10
Daily 14:50 Las Vegas Harry Reid (LAS) 1 21:58 Detroit (DTW) M
DL 421 Non-stop Boeing 757 (757) 4:08 Effective 2025-08-11 through 2025-08-29
Daily 14:50 Las Vegas Harry Reid (LAS) 1 21:58 Detroit (DTW) M
DL 421 Non-stop Boeing 757 (757) 4:08 Effective 2025-09-01 through 2025-09-07
Daily 14:50 Las Vegas Harry Reid (LAS) 1 21:52 Detroit (DTW) M
DL 421 Non-stop Boeing 757 (757) 4:02 Effective 2025-09-08 through 2025-10-05
Daily 14:50 Las Vegas Harry Reid (LAS) 1 21:53 Detroit (DTW) M
DL 421 Non-stop Airbus A321 (321) 4:03 Effective 2025-10-06 through 2025-12-19
Daily 14:50 Las Vegas Harry Reid (LAS) 1 21:53 Detroit (DTW) M
DL 421 Non-stop Airbus A321 (321) 4:03 Effective from 2026-01-06
Daily 15:00 Las Vegas Harry Reid (LAS) 1 22:00 Detroit (DTW) M
DL 421 Non-stop Boeing 757 (757) 4:00 Effective 2025-05-07 through 2025-06-07
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This flight number is listed as serving the following routes:
Delta Air Lines flight DL 421: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:

Delta Air Lines DL421
Effective 2025-06-08 through 2025-07-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:14, non-stop
Boeing 757 (757)

Delta Air Lines DL421
Effective 2025-12-20 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:35, non-stop
Airbus A321 (321)

Delta Air Lines DL421
Effective 2025-05-07 through 2025-06-07
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:23, non-stop
Boeing 757 (757)

Delta Air Lines DL421
Effective 2025-07-07 through 2025-08-10
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:18, non-stop
Boeing 737-900 (739)

Delta Air Lines DL421
Effective 2025-08-11 through 2025-09-07
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:18, non-stop
Boeing 757 (757)

Delta Air Lines DL421
Effective from 2026-01-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:44, non-stop
Airbus A321 (321)

Delta Air Lines DL421
Valid until 2025-05-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:25, non-stop
Airbus A321 (321)

Delta Air Lines DL421
Effective 2025-07-07 through 2025-08-10
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:08, non-stop
Boeing 737-900 (739)

Delta Air Lines DL421
Effective 2025-08-11 through 2025-08-29
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:08, non-stop
Boeing 757 (757)

Delta Air Lines DL421
Effective 2025-09-01 through 2025-09-07
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:08, non-stop
Boeing 757 (757)

Delta Air Lines DL421
Effective 2025-09-08 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:02, non-stop
Boeing 757 (757)

Delta Air Lines DL421
Effective 2025-10-06 through 2025-12-19
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:03, non-stop
Airbus A321 (321)

Delta Air Lines DL421
Effective from 2026-01-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:03, non-stop
Airbus A321 (321)

Delta Air Lines DL421
Effective 2025-05-07 through 2025-06-07
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:00, non-stop
Boeing 757 (757)
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This flight number is listed as serving the following routes:
  • Detroit (DTW) - Las Vegas Harry Reid (LAS)