Delta Air Lines flight DL 5621: Multiple routes

Ad box here 1220564027 I FlightWNum Top Box
Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Daily 06:00 New York LaGuardia (LGA) C 07:50 Chicago O'Hare (ORD) 5
DL 5621 Non-stop Embraer EMB 175 (E75) 2:50 Effective from 2026-01-06
Daily 08:30 Chicago O'Hare (ORD) 5 11:58 New York LaGuardia (LGA) C
DL 5621 Non-stop Embraer EMB 175 (E75) 2:28 Effective from 2026-01-06
Daily 15:58 Hilton Head Island (HHH) 18:09 New York LaGuardia (LGA) C
DL 5621 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:11 Effective 2025-06-08 through 2025-07-03
Sat,Sun 15:58 Hilton Head Island (HHH) 18:09 New York LaGuardia (LGA) C
DL 5621 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:11 Effective 2025-07-05 through 2025-07-06
Daily 15:58 Hilton Head Island (HHH) 18:14 New York LaGuardia (LGA) C
DL 5621 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:16 Effective 2025-07-07 through 2025-09-07
Daily 16:00 Hilton Head Island (HHH) 18:10 New York LaGuardia (LGA) C
DL 5621 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:10 Effective 2025-05-07 through 2025-06-07
Daily 17:25 Hilton Head Island (HHH) 19:38 New York LaGuardia (LGA) C
DL 5621 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:13 Valid until 2025-05-06
Daily 17:30 Hilton Head Island (HHH) 19:43 New York LaGuardia (LGA) C
DL 5621 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:13 Effective 2025-09-08 through 2025-10-26
Daily 17:40 New York John F. Kennedy (JFK) 4 20:02 Charleston (CHS)
DL 5621 Non-stop Embraer EMB 175 (E75) 2:22 Effective 2025-12-24 through 2026-01-03
Ad flat here 1377413384 I FlightWNum Lower
Parallax here
This flight number is listed as serving the following routes:


Feedback - Disclaimer - Privacy - new_base.html - DESKTOP - CACHE: False - LANG: en - IS_EU: False
FlightMapper.net Flight Search Countries Airlines
LANGUAGES
Delta Air Lines flight DL 5621: Multiple routes
Ad mobi flat here (320x100px) 6074960173 M FlightWNum Top Flat
Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Delta Air Lines DL5621
06:00
New York LaGuardia (LGA) C

07:50
Chicago O'Hare (ORD) 5
Effective from 2026-01-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:50, non-stop
Embraer EMB 175 (E75)
Delta Air Lines DL5621
08:30
Chicago O'Hare (ORD) 5

11:58
New York LaGuardia (LGA) C
Effective from 2026-01-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:28, non-stop
Embraer EMB 175 (E75)
Delta Air Lines DL5621
15:58
Hilton Head Island (HHH)

18:09
New York LaGuardia (LGA) C
Effective 2025-06-08 through 2025-07-03
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:11, non-stop
Embraer EMB 170 / EMB 175 (E70)
Delta Air Lines DL5621
15:58
Hilton Head Island (HHH)

18:09
New York LaGuardia (LGA) C
Effective 2025-07-05 through 2025-07-06
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
Duration: 2:11, non-stop
Embraer EMB 170 / EMB 175 (E70)
Delta Air Lines DL5621
15:58
Hilton Head Island (HHH)

18:14
New York LaGuardia (LGA) C
Effective 2025-07-07 through 2025-09-07
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:16, non-stop
Embraer EMB 170 / EMB 175 (E70)
Delta Air Lines DL5621
16:00
Hilton Head Island (HHH)

18:10
New York LaGuardia (LGA) C
Effective 2025-05-07 through 2025-06-07
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:10, non-stop
Embraer EMB 170 / EMB 175 (E70)
Delta Air Lines DL5621
17:25
Hilton Head Island (HHH)

19:38
New York LaGuardia (LGA) C
Valid until 2025-05-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:13, non-stop
Embraer EMB 170 / EMB 175 (E70)
Delta Air Lines DL5621
17:30
Hilton Head Island (HHH)

19:43
New York LaGuardia (LGA) C
Effective 2025-09-08 through 2025-10-26
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:13, non-stop
Embraer EMB 170 / EMB 175 (E70)
Delta Air Lines DL5621
17:40
New York John F. Kennedy (JFK) 4

20:02
Charleston (CHS)
Effective 2025-12-24 through 2026-01-03
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:22, non-stop
Embraer EMB 175 (E75)
Ad mobi box here (300x250px) 8888825773 M FlightWNum Bottom Box
Parallax here
This flight number is listed as serving the following routes:
  • Chicago O'Hare (ORD) - New York LaGuardia (LGA)
  • Hilton Head Island (HHH) - New York LaGuardia (LGA)
  • New York John F. Kennedy (JFK) - Charleston (CHS)
All Delta Air Lines flights
Feedback     -     Disclaimer     -     Privacy - new_base.html - MOBILE

- CACHE: False - LANG: en - IS_EU: False