United Airlines flight UA 4381: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Mon-Fri,Sun 10:36 Columbia (CAE) 12:00 Chicago O'Hare (ORD) 2
UA 4381 Non-stop Canadair CRJ 550 (CR5) 2:24 Effective 2026-03-05 through 2026-03-27
Daily 13:52 Buffalo (BUF) 15:01 Chicago O'Hare (ORD) 2
UA 4381 Non-stop Canadair CRJ 550 (CR5) 2:09 Effective 2026-02-12 through 2026-03-04
Daily 13:55 Buffalo (BUF) 14:48 Chicago O'Hare (ORD) 2
UA 4381 Non-stop Canadair CRJ 550 (CR5) 1:53 Effective from 2026-03-29
Daily 13:59 Buffalo (BUF) 15:04 Chicago O'Hare (ORD) 2
UA 4381 Non-stop Canadair CRJ 550 (CR5) 2:05 Valid until 2026-01-05
Sat 15:25 Newark Liberty, New York (EWR) C 17:46 Cincinnati (CVG)
UA 4381 Non-stop Canadair CRJ 550 (CR5) 2:21 Effective 2026-01-10 through 2026-02-07
Mon-Fri,Sun 15:55 Newark Liberty, New York (EWR) C 18:16 Cincinnati (CVG)
UA 4381 Non-stop Canadair CRJ 550 (CR5) 2:21 Effective 2026-01-06 through 2026-02-11
Sat 16:15 John Glenn Columbus (CMH) 16:56 Chicago O'Hare (ORD) 2
UA 4381 Non-stop Canadair CRJ 550 (CR5) 1:41 Effective 2026-03-07 through 2026-03-28
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This flight number is listed as serving the following routes:


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United Airlines flight UA 4381: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
United Airlines UA4381
10:36
Columbia (CAE)

12:00
Chicago O'Hare (ORD) 2
Effective 2026-03-05 through 2026-03-27
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:24, non-stop
Canadair CRJ 550 (CR5)
Direct Flights:
United Airlines UA4381
13:52
Buffalo (BUF)

15:01
Chicago O'Hare (ORD) 2
Effective 2026-02-12 through 2026-03-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:09, non-stop
Canadair CRJ 550 (CR5)
Direct Flights:
United Airlines UA4381
13:55
Buffalo (BUF)

14:48
Chicago O'Hare (ORD) 2
Effective from 2026-03-29
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:53, non-stop
Canadair CRJ 550 (CR5)
Direct Flights:
United Airlines UA4381
13:59
Buffalo (BUF)

15:04
Chicago O'Hare (ORD) 2
Valid until 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:05, non-stop
Canadair CRJ 550 (CR5)
Direct Flights:
United Airlines UA4381
15:25
Newark Liberty, New York (EWR) C

17:46
Cincinnati (CVG)
Effective 2026-01-10 through 2026-02-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:21, non-stop
Canadair CRJ 550 (CR5)
Direct Flights:
United Airlines UA4381
15:55
Newark Liberty, New York (EWR) C

18:16
Cincinnati (CVG)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:21, non-stop
Canadair CRJ 550 (CR5)
Direct Flights:
United Airlines UA4381
16:15
John Glenn Columbus (CMH)

16:56
Chicago O'Hare (ORD) 2
Effective 2026-03-07 through 2026-03-28
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:41, non-stop
Canadair CRJ 550 (CR5)
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This flight number is listed as serving the following routes:
  • Buffalo (BUF) - Chicago O'Hare (ORD)
  • Columbia (CAE) - Chicago O'Hare (ORD)
  • John Glenn Columbus (CMH) - Chicago O'Hare (ORD)
  • Newark Liberty, New York (EWR) - Cincinnati (CVG)
All United Airlines flights
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